SYNERGY: Study researching new treatment for people who have previously had depression

This study is investigating a new treatment for adults who have previously had depression but are still experiencing cognitive impact (e.g. issues with memory). This research is being carried out at the University of Oxford.

The study will involve 7 visits over 1 month, including 2 MRI scans. Participants will be paid £20 per hour for taking part in the study (an estimated total of £700) plus reasonable travel expenses.

Study For

Adults aged 25-55 who have previously had depression

Sponsored By

Syndesi Therapeutics. Conducted by Oxford University

Participants

30

People

Take Part

Deadline:

January 31, 2022

What is expected of me? 

The study will include taking the study drug each morning for 16 to 18 days and completing a number of questionnaires, memory and problem solving tasks. The study will include 7 visits to the study site (Warneford Hospital in Oxford), and two of these will include a magnetic resonance imaging (MRI) brain scan whilst completing some of the tasks.


This study is a ‘randomised’ study, which means that participants are put into one of 3 groups and each group is given a different treatment. Two doses of study drug, (1.0 mg SDI-118 or 5.0 mg SDI-118) or placebo (dummy drug) will be evaluated in 3 equal sized groups. Each participant will be put into one of the 3 groups by chance (randomly). You are more likely to receive study drug (approximately 67% chance) than placebo.

What is the benefit for me?

There are no direct benefits to you taking part in this study. However, the information we get from you will help us to understand more about the safety and tolerability of the study drug and how the study drug affects the performance of learning and memory tasks.

Participants will be paid £20 per hour for taking part in the study (an estimated total of £700) plus reasonable travel expenses.

Who is the study for? 

You must:

  • Be aged 25-55
  • Previously had depression that was treated with antidepressants or therapy
  • Have not been treated with antidepressants for at least 6 weeks
  • Be right-handed
  • Be experiencing impact to your memory (this will be determined by the study team)
  • Be willing to attend all 7 visits, including 2 MRI scans

Study Application Form

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