CABIN study: researching new treatment for people with low mood

This study is researching how antidepressants and behavioural therapy affect people who are experiencing low mood. The study hopes to develop better personalised treatment for low mood.

The study is looking for people who are feeling low in mood but who are not currently taking any medication to treat depression or receiving any type of psychological therapy. The study will involve 6 research visits, 1 in person at the research site at the University of Oxford and 5 online. You will receive £150 for participation.

Study For

Adults with low mood, who are not currently receiving any medication or therapy.

Sponsored By

University of Oxford




Take Part


September 1, 2022

What is expected of me? 

If you decide to take part in this study there are 2 screening appointments, one of which is in person at the Department of Psychiatry, University of Oxford (Maps).

If included in the study, you will be randomly allocated to receive two weeks of a commonly used antidepressant or a “placebo” (a dummy treatment). At the same time you may be allocated to receive behavioural therapy.  

There will be 4 online appointments and a daily online quick survey to complete over a two week period.

What is the benefit for me?

You are not expected to receive any direct benefit from taking part as this is only a 2-week treatment, however you may discuss continuing this with your GP or the research team. The study hopes to find a treatment for low mood which will have wider benefits.

You will receive £150 for participation in the study plus reasonable travel expenses.

Who is the study for? 

Participants must:

  • Be aged 18 - 65 
  • Feel low in mood and activity 
  • Not be currently taking any medication to treat depression, or have done so in the last six months 
  • Not receiving any type of psychological therapy 
  • Not have current or past diagnosis of any major mental health condition or addiction. This excludes diagnosis of depression and anxiety
  • Not be lactose intolerant 
  • Not be pregnant, breastfeeding or planning to become pregnant

Study Application Form

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